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Original Articles
- The Risk of Colorectal Cancer After Cholecystectomy or Appendectomy: A Population-based Cohort Study in Korea
- Joonki Lee, Sunho Choe, Ji Won Park, Seung-Yong Jeong, Aesun Shin
- J Prev Med Public Health. 2018;51(6):281-288. Published online October 29, 2018
- DOI: https://doi.org/10.3961/jpmph.18.105
- 7,870 View
- 220 Download
- 20 Crossref
-
Abstract
Summary
PDF
Supplementary Material - Objectives
We investigated the association between cholecystectomy or appendectomy and the subsequent risk of colorectal cancer (CRC) in the Korean population.
Methods
A retrospective cohort study was conducted with the National Health Insurance Service–National Sample Cohort of Korea; this sample was followed up from January 1, 2002, until the date of CRC incidence, loss to follow-up, or December 31, 2015. The exposure status of cholecystectomy and appendectomy was treated as a time-varying covariate. The calculated risk of CRC was stratified by follow-up period, and the association between these surgical procedures and CRC was investigated by a Cox regression model applying appropriate lag periods.
Results
A total of 707 663 individuals were identified for analysis. The study population was followed up for an average of 13.66 years, and 4324 CRC cases were identified. The hazard ratio (HR) of CRC was elevated in the first year after cholecystectomy (HR, 1.71; 95% confidence interval [CI], 1.01 to 2.89) and in the first year and 2-3 years after appendectomy (HR, 4.22; 95% CI, 2.87 to 6.20; HR, 2.34; 95% CI, 1.36 to 4.03, respectively). The HRs of CRC after applying 1 year of lag after cholecystectomy and 3 years of lag after appendectomy were 0.80 (95% CI, 0.57 to 1.13) and 0.77 (95% CI, 0.51 to 1.16), respectively.
Conclusions
The risk of CRC increased in the first year after cholecystectomy and appendectomy, implying the possibility of bias. When appropriate lag periods after surgery were applied, no association was found between cholecystectomy or appendectomy and CRC. -
SummaryKorean summary
본 연구는 담낭절제술, 충수돌기절제술 후 대장암의 발생위험에 관한 연구로 국민건강보험공단 표본코호트자료를 사용한 후향적코호트 연구이다. 총 707 663명을 대상으로 연구를 진행하였으며, 담낭절제술을 시행한 환자들은 수술 후 1년 이내에서 대장암의 위험도가 유의하게 증가하였으나 이후 관련성을 보이지 않았고, 충수돌기절제술을 시행한 환자들은 수술 후 1년, 2~3년에서 유의하게 위험도가 증가하였으나, 이후에는 관련성을 보이지 않았다. 이 결과는 역인과관계의 가능성을 시사하며 이것을 고려하였을 때, 담낭절제술과 충수돌기절제술은 대장암의 발생위험과의 연관성을 보이지 않았다. -
Citations
Citations to this article as recorded by
- Beyond a vestigial organ: effects of the appendix on gut microbiome and colorectal cancer
Daniel Ren Yi Yap, Rashid N Lui, Jens Samol, Joanne Ngeow, Joseph JY Sung, Sunny H Wong
Journal of Gastroenterology and Hepatology.2024;[Epub] CrossRef - Trends in colorectal cancer screening compliance and incidence among 60‐ to 74‐year‐olds in China
Mingqing Zhang, Yongdan Zhang, Lu Guo, Lizhong Zhao, Haoren Jing, Xiao Yang, Wen Zhang, Yong Zhang, Zhenguo Nie, Siwei Zhu, Shiwu Zhang, Xipeng Zhang
Cancer Medicine.2024;[Epub] CrossRef - The Appendix Orchestrates T-Cell Mediated Immunosurveillance in Colitis-Associated Cancer
Maxime K. Collard, Julien Tourneur-Marsille, Mathieu Uzzan, Miguel Albuquerque, Maryline Roy, Anne Dumay, Jean-Noël Freund, Jean-Pierre Hugot, Nathalie Guedj, Xavier Treton, Yves Panis, Eric Ogier-Denis
Cellular and Molecular Gastroenterology and Hepatology.2023; 15(3): 665. CrossRef - Risk of colorectal cancer in patients with appendicitis over the age of 40 years
Mei Sze Lee, Alben Thomas, John F. Pearson, Rachel Purcell, Francis Frizelle, Tamara Glyn
Colorectal Disease.2023; 25(4): 624. CrossRef - Risk of colorectal cancer after appendectomy: A systematic review and meta‐analysis
Zhuhui Liu, Xinyue Ma, Chunqi Zhu, Jing‐Yuan Fang
Journal of Gastroenterology and Hepatology.2023; 38(3): 350. CrossRef - Does postcholecystectomy increase the risk of colorectal cancer?
Zhenyu Dong, Ruixian Shi, Pengda Li, Xiaobiao Song, Fan Dong, Jianmin Zhu, Riga Wu, Zhi Liang, Mingyue Du, Jijun Wang, Zhigang Yang
Frontiers in Microbiology.2023;[Epub] CrossRef - The association between prescription drugs and colorectal cancer prognosis: a nationwide cohort study using a medication-wide association study
Hyeong-Taek Woo, Seung-Yong Jeong, Aesun Shin
BMC Cancer.2023;[Epub] CrossRef - Cholecystectomy Increases the Risk of Type 2 Diabetes in the Korean Population
Ji Hye Huh, Kyong Joo Lee, Yun Kyung Cho, Shinje Moon, Yoon Jung Kim, Eun Roh, Kyung-do Han, Dong Hee Koh, Jun Goo Kang, Seong Jin Lee, Sung-Hee Ihm
Annals of Surgery.2023; 278(2): e264. CrossRef - No association between cholecystectomy and risk of colorectal cancer: a meta-analysis of cohort studies
Lulin Yu, Wenjing Liu, Yici Yan, Yu Jiang, Xin Gao, Shanming Ruan
International Journal of Colorectal Disease.2023;[Epub] CrossRef - Operational Definitions of Colorectal Cancer in the Korean National Health Insurance Database
Hyeree Park, Yu Rim Kim, Yerin Pyun, Hyundeok Joo, Aesun Shin
Journal of Preventive Medicine and Public Health.2023; 56(4): 312. CrossRef - Factors influencing advanced colorectal neoplasm anatomic site distribution in China: An epidemiological study based on colorectal cancer screening data
Kailong Zhao, Hongzhou Li, Baofeng Zhang, Wenwen Pang, Suying Yan, Xinzhu Zhao, Xinyu Liu, Wanting Wang, Qiurong Han, Yao Yao, Tianhao Chu, Zhiqiang Feng, Qinghuai Zhang, Chunze Zhang
Cancer Medicine.2023; 12(24): 22252. CrossRef - Colorectal cancer risk following appendectomy: a pooled analysis of three large prospective cohort studies
Joseph A. Rothwell, Nagisa Mori, Fanny Artaud, Agnès Fournier, Marco Conte, Marie‐Christine Boutron‐Ruault, Simon S. M. Chan, Marc J. Gunter, Neil Murphy, Gianluca Severi
Cancer Communications.2022; 42(5): 486. CrossRef - Appendectomy and the subsequent risk of cancer: A prospective population-based cohort study with long follow-up
A.L. van den Boom, B.D.A. Lavrijssen, J. Fest, M.A. Ikram, B.H. Stricker, C.H.J. van Eijck, R. Ruiter
Cancer Epidemiology.2022; 77: 102120. CrossRef - Cholecystectomy-induced secondary bile acids accumulation ameliorates colitis through inhibiting monocyte/macrophage recruitment
Yun Liu, Jun Xu, Xinhua Ren, Yu Zhang, Ziliang Ke, Jianhua Zhou, Yang Wang, Yifan Zhang, Yulan Liu
Gut Microbes.2022;[Epub] CrossRef - A Review of Colorectal Cancer in Terms of Epidemiology, Risk Factors, Development, Symptoms and Diagnosis
Tomasz Sawicki, Monika Ruszkowska, Anna Danielewicz, Ewa Niedźwiedzka, Tomasz Arłukowicz, Katarzyna E. Przybyłowicz
Cancers.2021; 13(9): 2025. CrossRef - Increased Risk of Major Depressive Disorder After Cholecystectomy: A Nationwide Population-Based Cohort Study in Korea
Eun Hyo Jin, Kyungdo Han, Dong Ho Lee, Cheol Min Shin, Joo Hyun Lim, Hyuk Yoon, Nayoung Kim
Clinical and Translational Gastroenterology.2021; 12(4): e00339. CrossRef - Evaluating the distribution of the locations of colorectal cancer after appendectomy and cholecystectomy
Szabolcs Ábrahám, Tibor Németh, Ria Benkő, Mária Matuz, Aurél Ottlakán, Dániel Váczi, Attila Paszt, Zsolt Simonka, György Lázár
World Journal of Surgical Oncology.2020;[Epub] CrossRef - Smoking status before and after colorectal cancer diagnosis and mortality in Korean men: A population‐based cohort study
Doeun Jang, Sunho Choe, Ji Won Park, Seung‐Yong Jeong, Aesun Shin
Cancer Medicine.2020; 9(24): 9641. CrossRef - Prognosis of Patients with Colorectal Cancer with Diabetes According to Medication Adherence: A Population-Based Cohort Study
Sunho Choe, Joonki Lee, Ji Won Park, Seung-Yong Jeong, Young Min Cho, Byung-Joo Park, Aesun Shin
Cancer Epidemiology, Biomarkers & Prevention.2020; 29(6): 1120. CrossRef - Safety and efficacy of laparoscopic cholecystectomy in preschool children
Sajad Ahmad Wani, Gowher Nazir Mufti, Nisar Ahmad Bhat, Aejaz Ahsan Baba, Faheem Andrabi, Mudasir Hamid, Shahid Shazad
Journal of Pediatric Endoscopic Surgery.2019; 1(3): 119. CrossRef
- Beyond a vestigial organ: effects of the appendix on gut microbiome and colorectal cancer
- Diabetes Mellitus and Site-specific Colorectal Cancer Risk in Korea: A Case-control Study
- Hyeongtaek Woo, Jeeyoo Lee, Jeonghee Lee, Ji Won Park, Sungchan Park, Jeongseon Kim, Jae Hwan Oh, Aesun Shin
- J Prev Med Public Health. 2016;49(1):45-52. Published online December 22, 2015
- DOI: https://doi.org/10.3961/jpmph.15.029
- 9,641 View
- 159 Download
- 12 Crossref
-
Abstract
PDF
- Objectives
Previous large-scale cohort studies conducted in Korea have found a positive association between diabetes mellitus (DM) and colorectal cancer (CRC) in men only, in contrast to studies of other populations that have found significant associations in both men and women.
Methods
A total of 1070 CRC cases and 2775 controls were recruited from the National Cancer Center, Korea between August 2010 and June 2013. Self-reported DM history and the duration of DM were compared between cases and controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by binary and polytomous logistic regression models.
Results
DM was associated with an elevated risk of CRC in both men (OR, 1.47; 95% CI, 1.13 to 1.90) and women (OR, 1.92; 95% CI, 1.24 to 2.98). This association remained when we controlled for age, body mass index, alcohol consumption, and physical activity level. In sub-site analyses, DM was associated with distal colon cancer risk in both men (multivariate OR, 2.04; 95% CI, 1.39 to 3.00) and women (multivariate ORs, 1.99; 95% CI, 1.05 to 3.79), while DM was only associated with rectal cancer risk in women (multivariate OR, 2.05; 95% CI, 1.10 to 3.82). No significant association was found between DM and proximal colon cancer risk in either men (multivariate OR, 1.45; 95% CI, 0.88 to 2.41) or women (multivariate OR, 1.79; 95% CI, 0.78 to 4.08).
Conclusions
Overall, DM was associated with an increased risk of CRC in Koreans. However, potential over-estimation of the ORs should be considered due to potential biases from the case-control design. -
Summary
Citations
Citations to this article as recorded by- The interaction between glycemic index, glycemic load, and the genetic variant ADIPOQ T45G (rs2241766) in the risk of colorectal cancer: a case–control study in a Korean population
Y-Thanh Lu, Madhawa Gunathilake, Jeonghee Lee, Jae Hwan Oh, Hee Jin Chang, Dae Kyung Sohn, Aesun Shin, Jeongseon Kim
European Journal of Nutrition.2022; 61(5): 2601. CrossRef - Expression of long non-coding RNA H19 in colorectal cancer patients with type 2 diabetes
Ming Zhao, Hantao Wang, Jingbo Chen, Yang Xi, Fuyan Wang, Cuilan Huo, Wenwen Li, Yudong Chu, Pengjie Xu, Qin Huang, Shizhong Bu
Archives of Physiology and Biochemistry.2021; 127(3): 228. CrossRef - Lymphocyte‐to‐monocyte ratio combined with CA19‐9 for predicting postoperative recurrence of colorectal cancer in patients with diabetes
Dan Yu, Guangyu An, Jiannan Yao
Journal of Clinical Laboratory Analysis.2021;[Epub] CrossRef - Sex- and site-specific differences in colorectal cancer risk among people with type 2 diabetes
Jetty A. Overbeek, Josephina G. Kuiper, Amber A. W. A. van der Heijden, Mariette Labots, Ulrike Haug, Ron M. C. Herings, Giel Nijpels
International Journal of Colorectal Disease.2019; 34(2): 269. CrossRef - Metabolic Syndrome and Risk of Colorectal Cancer: A Case-Control Study
Elham Davtalab Esmaeili, Khairollah Asadollahi, Ali Delpisheh, Kourosh Sayehmiri, Hosein Azizi
International Journal of Cancer Management.2019;[Epub] CrossRef - Colorectal Cancer Risks According to Sex Differences in Patients With Type II Diabetes Mellitus: A Korean Nationwide Population-Based Cohort Study
Ji Min Lee, Kang-Moon Lee, Dae Bum Kim, Seung-Hyun Ko, Yong Gyu Park
Clinical and Translational Gastroenterology.2019; 10(10): e00090. CrossRef - The association between plasma C-peptide concentration and the risk of prostate cancer: a nested case–control study within a Japanese population-based prospective study
Grace Y. Kiyabu, Norie Sawada, Motoki Iwasaki, Taiki Yamaji, Taichi Shimazu, Shizuka Sasazuki, Manami Inoue, Shoichiro Tsugane
European Journal of Cancer Prevention.2018; 27(5): 461. CrossRef - Association between Cardiovascular Risk and Diabetes with Colorectal Neoplasia: A Site-Specific Analysis
David Niederseer, Isabelle Bracher, Andreas Stadlmayr, Ursula Huber-Schönauer, Martin Plöderl, Slayman Obeid, Christian Schmied, Sabrina Hammerl, Felix Stickel, Dieter Lederer, Wolfgang Patsch, Elmar Aigner, Christian Datz
Journal of Clinical Medicine.2018; 7(12): 484. CrossRef - Optimal glycemic target level for colon cancer patients with diabetes
Shin Jun Lee, Jae Hyun Kim, Seun Ja Park, So Young Ock, Su Kyoung Kwon, Young Sik Choi, Bu Kyung Kim
Diabetes Research and Clinical Practice.2017; 124: 66. CrossRef - Impact of detection bias on the risk of gastrointestinal cancer and its subsites in type 2 diabetes mellitus
R.G.P.J. de Jong, A.M. Burden, S. de Kort, M.P.P. van Herk-Sukel, P.A.J. Vissers, P.K.C. Janssen, H.R. Haak, A.A.M. Masclee, F. de Vries, M.L.G. Janssen-Heijnen
European Journal of Cancer.2017; 79: 61. CrossRef - Effects of interactions between common genetic variants and smoking on colorectal cancer
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Mirabella Zhao, Donghua Liao, Jingbo Zhao
World Journal of Diabetes.2017; 8(6): 249. CrossRef
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